Mounjaro has become increasingly popular, and for good reason. This clinically proven injection has shown powerful results for weight loss, helping people lose up to 22.5% of their body weight over 72 weeks on a 15mg weekly dose.
But Mounjaro is not a miracle medicine. It works best alongside a healthy diet, lifestyle changes, and consistent effort. Think of it as a support system that helps you lose weight, but it cannot do the work alone. When used correctly, Mounjaro can help reset your relationship with food and give you the boost needed to achieve long-term results.
In this article, we’ll guide you through what results to expect from Mounjaro, week by week. From the early adjustment phase to long-term progress, you’ll learn how your body may respond and how to stay on track throughout the journey.
Whether you’ve just started taking Mounjaro or you’re researching what to expect in the weeks ahead, this guide will help you understand the process and feel more confident about what’s to come.
💡 If you’re considering starting Mounjaro, our qualified clinicians can assess your suitability and guide you through the first steps. Book an online or in-person consultation →
Starting mounjaro
Everyone begins Mounjaro with a 2.5mg dose of tirzepatide. This is the standard starting point for all patients. The injection is taken once a week, ideally on the same day and at roughly the same time each week. While it doesn’t have to be exact to the hour, keeping it consistent helps maintain steady levels of the medication in your body. A regular routine can also make it easier for your body to adjust, which may reduce side effects and improve your overall results.
What to expect in your first week of Mounjaro
In your first week of taking Mounjaro, you’ll be starting on the lowest dose of tirzepatide. This medicine works by copying two natural hormones that help manage your appetite and how your body uses energy. One helps you feel full for longer, and the other helps your body balance energy more effectively. Together, they can help reduce cravings and slow down digestion.
Weight loss with Mounjaro takes time. There won’t be a dramatic difference straight away, and results will vary from person to person. Some people might see a quick drop in weight, while others might not notice any changes during the first week.
If you do notice a sudden drop, it’s likely water weight. When you eat fewer calories, your body starts to release glycogen, which is stored energy. Every gram of glycogen is stored with 3g of water, so when glycogen is used, the water is released too. That water leaves your body as waste through urine, faeces, and sweat.
Some people may experience mild side effects during the first week. These can include feeling sick, diarrhoea, constipation, stomach cramps, or headaches. If the side effects feel too strong, you can stay on the same dose for longer before increasing it. This gives your body a bit more time to adjust to the current dosage and overcome the side effects.
Mounjaro Week 2
Week 2 on Mounjaro is likely to feel very similar to week 1, as the dosage remains the same for the first four weeks. You’ll still be taking 2.5mg once a week, giving your body time to adjust gradually.
Some people may begin to notice stronger effects in Week 2. This could include increased appetite control or more noticeable weight loss. For others, this might be the point when early side effects start to ease, especially if they were mild to begin with.
It’s important to remember that Mounjaro is not a quick fix. To get the most from it, you’ll need to follow a healthy diet and stay active. Combining Mounjaro with balanced meals and regular exercise will support long-term weight loss and help you feel your best throughout treatment.
You don’t need to burn yourself out with intense workouts – even small changes, like aiming for 1,000 to 2,000 steps a day at first, can help. Combining Mounjaro with balanced meals and light movement will support long-term weight loss and help you feel your best throughout treatment.
Mounjaro Weeks 3 and 4
By weeks 3 and 4, most people find that the side effects have eased significantly. Since you’re still on the starting dose of 2.5mg, your body should now be well adjusted to the medication and the weekly injection routine.
Research shows that some patients lose up to 4% of their body weight in the first month alone. While everyone’s experience is different, the effects of Mounjaro often become more noticeable around this time. Many people feel fuller for longer and start seeing the benefits of reduced appetite and fewer cravings.
To get the most out of your Mounjaro treatment, it’s important to continue with a healthy lifestyle. A calorie-controlled diet and regular physical activity will help support your progress and improve long-term results.
Mounjaro Weeks 5 to 8 – Increasing your dosage
At this stage, your Mounjaro dose will increase from 2.5mg to 5mg. You’ll stay on this dose for the next four weeks.
It’s important to remember that this is just a general timeline. Your journey may look different depending on how your body responds. At Longridge Travel Health Clinic, we’ll have regular check-ins to review your progress and decide together whether it’s time to increase your dose or remain where you are. It’s all tailored to your individual needs.
💡 All our patients receive ongoing monitoring and tailored dose reviews as part of their treatment plan. Start your Mounjaro journey with a free consultation →
Many people lose around 5 to 6% of their body weight during this time, although this figure is just an average. If your results are different, that’s completely normal. Progress varies, and the number on the scale doesn’t tell the full story.
Avoid weighing yourself daily. It can be mentally exhausting and won’t reflect true fat loss. Your weight naturally goes up and down from things like water retention, hormones, and digestion. It’s better to weigh yourself every couple of weeks so you can focus on the bigger picture.
Since the dose has increased, some of the side effects from earlier weeks might return. This happens to many people and usually settles on its own. If you find the symptoms difficult or they begin to affect your daily life, speak to a healthcare provider. They can help you decide whether to continue, pause, or adjust your plan.
By now, you may notice a stronger reduction in appetite. Feeling full sooner and experiencing fewer cravings can make it easier to follow your diet and stay on track.
Keeping up healthy habits like a balanced diet and regular exercise gives Mounjaro the best chance to work effectively, and it also lays the foundation for long-term success. The more consistent you are now, the easier it becomes to maintain your results after treatment ends
Mounjaro Weeks 9 to 12
Week 9 is when your dose increases again, this time from 5mg of tirzepatide to 7.5mg. You’ll remain on this dose for the next four weeks. Studies show that participants can lose around 8 to 9% of their total body weight by this stage. As always, results will vary depending on the individual, so try not to compare your progress too closely to others.
Another dose increase may trigger a return or slight increase in side effects such as diarrhoea, constipation and headaches. This is normal and often temporary, but there are some simple ways to manage them:
- Eat smaller meals more frequently
- Drink plenty of water throughout the day
- Get enough rest to help your body adjust
- Use over-the-counter remedies if you have symptoms like constipation or diarrhoea
- Keep moving with gentle exercise, even a walk can help
If the side effects start to feel unmanageable or your symptoms worsen, don’t wait it out. Reach out to your healthcare provider or contact us at Longridge Travel Health Clinic for support. You’re not expected to go through it alone, and sometimes a slight adjustment is all that’s needed.
Mounjaro – Week 13 and beyond
By week 13, your Mounjaro dose will increase to 10mg. From this point forward, the dosage will continue to increase every four weeks until you reach the maximum dose of 15mg by week 21. Once you reach 15mg, you’ll remain on that dose for the rest of your treatment. Total treatment times will vary based on individual needs, goals, and preferences. We’ll work closely with you to ensure your journey works for you.
As your dose increases, you may notice that appetite suppression becomes stronger. You’ll still feel hunger at times, but it should be much easier to reduce your calorie intake and stick to smaller portion sizes. Many people find that they naturally stop snacking as often or begin to lose interest in sugary foods.
If you’re still snacking frequently or turning to sugary foods, it could be more about habit than true hunger. This is very common. Reach out to us, and we can help advise you on next steps, especially if you’re feeling stressed. Support is available, and you don’t have to break those habits on your own.
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Do I have to increase Mounjaro dosage every 4 weeks?
No, you do not. While many people follow the standard schedule of increasing their dose every four weeks, it is completely fine to stay on a lower dose for longer. You can increase your dosage when you feel ready. Normally, it’s best to work closely with your healthcare provider who can work with you to track your progress and advise you on the best course of action.
How much weight can I actually lose on Mounjaro?
Mounjaro is a long-term treatment that works best when combined with a healthy diet and regular exercise. These habits also help you maintain your results after you stop taking the medication.
In clinical studies, patients taking the 15mg dose for 72 weeks lost up to 22.5 percent of their body weight. Nearly all participants lost at least 5 percent. If you continue your healthy habits afterwards, your results can be even better.
Conclusion
Losing weight with Mounjaro takes time, patience, and the right support. Whether you’re just starting out or already a few weeks in, having expert advice and guidance can make a big difference.
At Longridge Travel Health Clinic, we offer Mounjaro as part of our weight loss services, along with personalised support and follow-up care to help you stay on track. If you’re ready to begin or want to learn more, get in touch with us today.
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