Coeliac/Gluten Sensitivity Profile
Identify whether gluten is causing symptoms such as bloating, fatigue, or digestive discomfort. This test screens for coeliac disease-specific antibodies and gluten sensitivity markers. Gain clarity and take control of your gut health.
- Description
- Why This Test?
- Associated Conditions
- Uses of This Test
The Coeliac/Gluten Sensitivity Profile is a targeted blood test designed to support the investigation of immune reactions to gluten. It can help identify patterns consistent with coeliac disease and provide useful insight when symptoms suggest gluten may be triggering digestive or systemic issues.
Gluten-related conditions are often under-recognised because symptoms can be wide-ranging and overlap with other gastrointestinal disorders. This test supports earlier detection, helping to reduce the risk of prolonged discomfort, unnecessary dietary restriction, or long-term complications linked to untreated immune reactions.
It is particularly useful when symptoms occur after eating gluten-containing foods, when there is a family history of coeliac disease, or when someone is considering dietary changes and wants a clinical baseline. Important: For accurate testing, you should be consuming gluten regularly before the test. Starting a gluten-free diet beforehand may reduce antibody levels and affect interpretation.
Coeliac disease is an autoimmune condition in which the immune system reacts to gluten and damages the lining of the small intestine. Over time, this can affect nutrient absorption and contribute to symptoms and complications such as persistent digestive discomfort, fatigue, anaemia, and vitamin or mineral deficiencies.
Early detection matters because untreated coeliac disease may lead to:
- Ongoing gastrointestinal symptoms and inflammation
- Nutrient deficiencies (including iron, folate, and vitamin B12)
- Anaemia and persistent fatigue
- Longer-term health complications due to malabsorption
Some people experience symptoms triggered by gluten despite not having coeliac disease. This is sometimes referred to as non-coeliac gluten sensitivity. Symptoms can overlap with coeliac disease (such as bloating, fatigue, and digestive discomfort), but the underlying mechanism is different.
This profile helps clinicians assess whether the immune system is reacting in a way that is more suggestive of coeliac disease and can support differentiation from other gluten-related concerns.
Coeliac Disease
An autoimmune condition triggered by gluten that damages the small intestine lining and can lead to malabsorption, digestive symptoms, and nutrient deficiencies.
Non-Coeliac Gluten Sensitivity
A condition where gluten triggers symptoms such as bloating, fatigue, and digestive discomfort without the same autoimmune intestinal damage seen in coeliac disease.
Unexplained Anaemia
Coeliac disease is a recognised cause of iron deficiency anaemia due to impaired absorption and ongoing intestinal inflammation.
- Investigate digestive symptoms linked to gluten
- Check possible gluten sensitivity
- Explore unexplained fatigue or low energy
- Investigate unexplained anaemia
- Screening with family history of coeliac disease
What We Test
Biomarkers analysed by accredited UK laboratories
Biomarkers Tested
Coeliac / Gluten Sensitivity Markers
- Immunoglobulin A (IgA)
If IgA is low (IgA deficiency), coeliac-related IgA markers may appear falsely normal, so this result is essential for accurate interpretation of the profile.
- Tissue Transglutaminase IgA (tTG-IgA)
Elevated levels strongly suggest an autoimmune reaction to gluten that is consistent with coeliac disease.
- Gliadin Antibodies (IgG, deamidated)
Deamidated gliadin IgG helps detect gluten-related immune reactivity, particularly in people with IgA deficiency or where tTG-IgA is less informative.
- Immunoglobulin A (IgA)
In-Clinic Blood Testing At Longridge, Preston
If you’d rather leave everything to a qualified professional, our in-clinic blood testing service is the most comfortable and hands-off experience. Once you complete your order, we’ll contact you to arrange a convenient appointment time.
Your sample will be taken by a trained phlebotomist, making the process quick, smooth, and reassuring - especially if you’re nervous around blood or struggle with finger-prick tests.
We send off all samples the same day to the lab to be processed so results can be expected within 72 hours.
Why Use This Service:
Hands-off, professional experience
High-quality samples for complex tests
No risk of “not enough sample”
Support at every step
No posting or packaging required
Convinient appointment times
Taking Charge Of Your Own Health Has Never Been Easier
Worried about your wellbeing?
If you’re experiencing unexplained symptoms such as fatigue, weight loss, or other issues, a comprehensive blood test may be the key to discovering potential underlying health problems.
Need to monitor a health condition?
Blood tests offer essential insights into various aspects of your health, from detecting deficiencies to evaluating immune functions.
Enhancing Performance and Fitness?
Whether you’re training for a sport or keeping track of your fitness progress, a blood test serves as an excellent foundation for your performance improvement journey.
All Our Tests Include:
No GP Referral
Order directly - no waiting for appointments
Fast Results
Detailed analysis within 72 hours
Doctor's Commentary
Expert interpretation of your results included
Secure & Confidential
Discreet service and consultations
Frequently Asked Questions
- Qualified Pharmacists
- Flexible Appointments
- Top Customer Service
How accurate are home finger-prick tests compared to clinic tests?
Our home finger-prick tests use the same accredited laboratories as our clinic tests. While clinic tests allow for more comprehensive panels, home tests are highly accurate for the parameters they measure.
Do I need a GP referral for a blood test?
No, you don’t need a GP referral. You can book directly with us for any blood test. We are a private clinic offering direct access to comprehensive blood testing.
How old do I have to be to have a blood test?
We will only draw blood from those aged 16 and above due to legal requirements.
How long does it take for the blood test results to come?
If you have used our clinic to complete a blood test, we send off all samples the same day to the lab to be processed. If you have used a home test kit, then once your sample has been sent off the lab will analyse your sample. Results are usually received within 72 hours.
How do I perform the home finger-prick test?
Your home blood test kit will contain easy-to-follow instructions on how to take your own finger blood sample. If you have any concerns or questions prior to using the kit, please contact our phlebotomists who will be happy to assist.
How do I prepare for a blood test?
There is no preparation required prior to taking any of the blood tests. Please simply remember to stay hydrated prior to your appointment. This is to help your veins dilate better to enable a quick and efficient blood sample to be taken and reduce the risks of feeling faint following your blood test.
Please inform the phlebotomist before your test if you are currently taking any blood thinning medication.
Should I fast before my blood test?
Fasting is not required for most blood tests. However, if your profile includes cholesterol tests and you’ve previously had high levels, consider fasting for 8 hours beforehand. While not essential, fasting can provide more accurate results.
Note: Fasting means abstaining from any food and drink, except for water.